In vitro protective effect of bacteria-derived bovine alpha interferon I1 against selected bovine viruses.

Inhibition of lymphocyte proliferation by bovine trophoblast protein-1 (type I trophoblast interferon) and bovine interferon-alpha I1.

Bovine trophoblast protein-1 (bTP-1) is a Type I interferon secreted by the bovine trophoblast from about Day 15 of pregnancy. It is not known whether bTP-1 has functional properties in common with other interferons. The aim of the present study was to determine whether bTP-1 inhibits proliferation of lymphocytes induced by mitogens, mixed lymphocyte cultures (MLC) and interleukin-2 (IL-2) and,...

Serological study of bovine viral respiratory diseases in dairy herds in Kerman province, Iran

Respiratory disorders are major concern for dairy cattle industry. Viruses and bacteria in combinationwith stress play a key role in triggering acute respiratory infections. The most important viral agents arebovine viral diarrhoea virus (BVDV), bovine herpes virus type 1 (BHV-1), bovine respiratory syncytial virus(BRSV), parainfluenza virus type 3 (PIV-3) and bovine adenovirus (BAV). This cros...

Protective Effects of Interleukin-4 on Tissue Destruction and Morphological Changes of Bovine Nasal Chondrocytes in vitro

Background: Previous studies have shown that some cytokines have protective effects on cartilage in joint diseases. In the current study, effects of IL-4 against morphological changes and tissue degradation induced by IL-1α on bovine nasal cartilage (BNC) explants were investigated. Methods: Fresh BNC samples were prepared from a slaughterhouse under sterile conditions. BNC explants culture was...

Seroepidemological Survey for Antibodies against Infectious Bovine Rhinotracheitis and Bovine Herpes 4 Viruses among Cattle in Different Provinces of Iran.

Spectrum of virus inhibition by consensus interferon YM643.

The spectrum of viruses inhibited by a genetically engineered consensus interferon (IFN) YM643 (interferon alfacon-1) was evaluated using a cytopathic effect inhibition assay or plaque inhibition assay for five DNA viruses and 12 RNA viruses. This activity was compared to that of natural IFN-alpha derived from Namalwa lymphoblastoid cell line [IFN-alpha (Namalwa)]. The viruses inhibited by both...